Book Hotels in Eastern Panama

Cabins, apartments, houseboats! We offer comfortable & private vacation rentals

Save an extra 10% or more on select hotels with Member Discounts

Access exclusive hotel deals, only with the Travelocity app

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Traveler experience
Traveler experience
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility

Top Eastern Panama hotels

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
$440 nightly
The price is $490 total per night from Mar 17 to Mar 18
$490 total
Mar 17 - Mar 18
Total with taxes and fees
This smoke-free resort features a private beach, a full-service spa, and 2 restaurants. Relax with free beach cabanas, sun loungers, and beach umbrellas. Relax ...
The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.

Reviewed on Feb 21, 2026

Opens in a new windowOrdovician Beach Resort
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11 El Llano Panamá Province
Fully refundableReserve now, pay when you stay
A restaurant and a bar/lounge are featured at this hotel. Guests will appreciate freebies like continental breakfast and free self parking. A coffee shop, a ...
Great location for bird watching! The hosts were friendly and helpful. It is best to contact them directly using WhatsApp in addition to booking on Expedia.

Reviewed on Feb 13, 2026

Opens in a new windowKonsenda San Blas
Discovery Gunayar

Discovery Gunayar

2 out of 5
Archipiélago de San Blas Narganá Guna Yala
Book a stay at this beach lodge in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime and Isla ...
Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done.

Reviewed on Jan 13, 2025

Opens in a new windowDiscovery Gunayar
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
This hotel features a restaurant, a bar/lounge, and a beach bar. If you want to take your pet along, this pet-friendly property offers everything you'll need ...
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.

Reviewed on Feb 4, 2026

Opens in a new windowHOTEL ISLA GRANDE
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $107 total per night from Mar 16 to Mar 17
$107 total
Mar 16 - Mar 17
Total with taxes and fees
This smoke-free hotel features 20 restaurants and 20 bars/lounges. Enjoy a meal in one of the 19 coffee shops/cafes and free perks like cooked-to-order breakfast ...
Opens in a new windowHotel Cocotal
 San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island Ailigandi Guna Yala
Book a stay at this beach hotel in Ailigandí. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
Opens in a new window San Blas Paradise Private Cabins on Shipwreck Island - meals included
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,746 nightly
The price is $1,926 total per night from Apr 10 to Apr 11
$1,926 total
Apr 10 - Apr 11
Total with taxes and fees
A restaurant and a bar/lounge are featured at this property. Guests will appreciate free perks like continental breakfast and WiFi in public areas. A coffee ...
Opens in a new windowCocoloco - Catamaran Lagoon 52F SAN BLAS
San Blas Private Beach Cabin

San Blas Private Beach Cabin

2.5 out of 5
Nusatupo Narganá Guna Yala
This cabin features a restaurant, an area shuttle, and a terrace. Enjoy the free continental breakfast each morning. Barbecue grills are provided for your ...
Opens in a new windowSan Blas Private Beach Cabin
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
This hotel features a restaurant, a garden, and a snack bar/deli. Enjoy the free local cuisine breakfast each morning.
Opens in a new windowPrivate Ocean-Front Cabin with private bathroom on San Blas Island
Don't see what you're looking for?
See all available properties in Eastern Panama
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Recent Eastern Panama hotel reviews by fellow wanderers